Matt McGloin started the past six games for the Raiders, who have lost five in a row.
Pryor has completed 57.7 percent of his passes this season for 1,591 yards, five TDs and 11 interceptions. He also has 527 yards rushing, including a 93-yard TD run against Pittsburgh.
McGloin, a rookie out of Penn State, has completed 55.9 percent of his throws for 1,547 yards, eight TDs and eight interceptions.